Cost, effects, applications, dosage, and additional details regarding Voranigo
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Meet Voranigo, a brand-name oral tablet used to tackle certain brain tumors. The active ingredient in this little pill is vorasidenib.
Uptight government types, the Food and Drug Administration (FDA), have approved Voranigo to treat grade 2 astrocytomas and oligodendrogliomas in grown-ups and teenagers aged 12 years and above. When your physician deems it necessary, they might prescribe Voranigo to handle these brain tumors. For more information, check out the "Voranigo uses" section.
Drug specifics
Here's a quick breakdown of Voranigo:
- Drug class: isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitor, which is a type of targeted cancer therapy
- Generic available? no way, bruh!
- Prescription needed? yup, so don't waste your time at the drugstore without it
- Controlled substance? nah, this ain't one of those - but it could still mess you up if you don't take it right
Voranigo's generic
You can only snag Voranigo in its brand-name glory - there's no generic form of it on the market.
A generic drug copies the active ingredient in a brand-name medication. Generics are generally cheaper, but... not this time, pal.
Voranigo cost and coupons
Like all medications, the price of Voranigo can vary. The actual cost depends on your insurance plan, your location, and the pharmacy you choose.
Money trouble? Help is on the way. There's a program called ServierONE for those needing financial support to pay for Voranigo - or if you're confused about your insurance coverage, they got your back!
Give them a call at 800-813-5905 or visit their program website for more info.
Voranigo's side effects
Voranigo can cause mild or serious side effects. This list contains a few examples. Don't expect every side effect to show up, though - some may go away within a few days to a couple of weeks. Serious side effects aren't common, but if they occur, call your doctor pronto.
Mild side effects
- Tiredness
- Headache
- Nausea
- Diarrhea
- CONSTIPATION
- Reduced appetite
- Muscle or joint pain/stiffness
- COVID-19
- Decreased white blood cell count
- Increased liver enzymes
Serious side effects
- Liver problems:
- Upper right abdominal pain
- Loss of appetite
- Severe tiredness or weakness
- Dark urine
- Yellowing of the skin or eyes (jaundice)
- Seizures
For some, Voranigo might cause an allergic reaction. But in the studies, this side effect wasn't reported.
less than 40 kg (about 88 pounds [lb])
For mild allergic reaction symptoms, such as a rash, holler at your doctor - they might have some advice to help manage it. For severe symptoms, like swelling or trouble breathing, call 911 or your local emergency number immediately. These symptoms need urgent medical treatment.
Voranigo uses
Voranigo for certain brain tumors
Voranigo treats specific brain tumors in adults and children aged 12 years and older: grade 2 astrocytomas and oligodendrogliomas.
20 mg once per day
These tumors are part of a group of brain tumors known as gliomas. Astrocytomas start in brain cells called astrocytes, while oligodendrogliomas start in brain cells called oligodendrocytes.
Voranigo for children
Voranigo has been approved for use in children aged 12 years and older to treat grade 2 astrocytomas and oligodendrogliomas with a certain genetic mutation.
Voranigo hasn't been tested in children younger than 12 years old. It's unknown whether it's safe or effective for this age group.
Voranigo dosage
Your doctor will decide the Voranigo dosage based on factors such as your age and weight, as well as whether any side effects appear during treatment.
- Forms and strengths: Voranigo is available as an oral tablet in strengths of 10mg and 40mg.
- Dosage for certain brain tumors: The standard recommended dosage for adults is 40mg once per day. In kids, the dosage depends on body weight:
| Child's weight in kilograms (kg) | Dosage || --- | --- || Less than 40kg (about 88 lbs) | 20mg once per day || 40kg or more | 40mg once per day |
40 kg or more
About taking Voranigo
Here's some important information regarding administering Voranigo:
- When to take: Take Voranigo once daily, but stick to a regular schedule to maintain a consistent level of the drug in your body.
- Missed dose: If you skip a dose, take it as soon as possible if 6 hours have passed. If it's been more than 6 hours, skip the missed dose and stay with your regular schedule. No double dipping!
- With food: You can take Voranigo with or without food.
- Pill disintegration: Don't crush, split, or chew the tablets. If you have trouble swallowing them, reach out to your doctor or pharmacist.
- Long-term use: Voranigo is meant to be a long-term treatment. Your doctor will continue prescriptions if Voranigo is safe and effective for you.
- Immediate effects: Voranigo starts working immediately, but you might not see instant results. The drug helps slow the growth of the brain tumor and prevents it from advancing.
Overdose
40 mg once per day
Overdosing on Voranigo isn't cool, so stick to the prescriptions. Taking more than directed can result in unwanted side effects.
If you suspect an overdose: Call your doctor right away, or chat with America's Poison Centers at 800-222-1222 or use their online tool. If you've had a serious overdose, call 911 or your local emergency number immediately.
Voranigo interactions
Voranigo might interact with several other medications.
Before taking Voranigo, inform your doctor and pharmacist about every medication you're using, including prescription drugs, over-the-counter items, herbal supplements, and vitamins.
Alcohol interaction
Consuming alcohol while taking Voranigo could create similar side effects, such as headaches, nausea, and liver problems. If you have questions, talk with your doctor or pharmacist.
Alternatives
Other treatments for brain tumors are viable options. Chat with your doctor about finding a suitable replacement for Voranigo if you prefer.
The following treatments are alternatives to Voranigo:
- Chemotherapy with drugs such as:
- PCV combination regimen (procarbazine, lomustine, and vincristine)
- temozolomide
- Radiation therapy
Things to consider when taking Voranigo
If you're pregnant or could become pregnant, consider these factors.
Voranigo and pregnancy
Voranigo isn't recommended during pregnancy because it may harm the fetus. If you're pregnant, speak with your doctor about your treatment options.
Voranigo and fertility
• ciprofloxacin (Cipro)• cyclosporine (Neoral, others)• fluvoxamine (Luvox)• phenytoin (Dilantin, Phenytek)• rifampin (Rifadin, Rimatane)• hormonal forms of birth control, such as the combined pill, minipill, or patch
Voranigo may reduce fertility in both males and females when taking the medication. If you plan to conceive in the future, discuss alternatives with your doctor before starting Voranigo treatment.
Voranigo and birth control
Voranigo is not safe during pregnancy, so use a non-hormonal form of birth control, like condoms, while taking Voranigo and for 3 months after finishing. Hormonal birth control methods, such as the pill, patch, or minipill, could be less effective while taking Voranigo.
How Voranigo works
Voranigo targets certain brain tumors called grade 2 astrocytomas and oligodendrogliomas. It's used for tumors of this type that have a specific genetic mutation.
A genetic mutation is an abnormal change in a gene. A gene is a piece of DNA that carries instructions for making proteins.
Voranigo is approved for tumors that have a mutation in the gene for isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2). IDH1 and IDH2 are enzymes that help cells produce energy.
When the gene for these enzymes is mutated, the enzymes don't work properly. Instead, they generate unwanted molecules that help tumor cells grow.
What Voranigo does
Voranigo inhibits the action of abnormal IDH1 and IDH2 enzymes in tumor cells. This reduces tumor cell growth, which helps to slow down the growth and deterioration of the brain tumor.
Voranigo is a brand-name oral tablet used to treat certain brain tumors, specifically grade 2 astrocytomas and oligodendrogliomas, in individuals aged 12 years and older. Approved by the Food and Drug Administration (FDA), this drug is an isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitor, a type of targeted cancer therapy.
There's no generic form of Voranigo available on the market, and it requires a prescription. The drug can be taken with or without food, but it's essential to adhere to a regular schedule for consistent results. If a dose is missed and it has been less than 6 hours, take it as soon as possible; if it has been more than 6 hours, skip the missed dose and stay with the regular schedule.
Voranigo can cause mild or serious side effects, such as tiredness, headache, nausea, diarrhea, constipation, reduced appetite, muscle or joint pain/stiffness, and liver problems. In the case of a serious side effect or an allergic reaction, prompt medical attention is necessary.
In studies, Voranigo hasn't been reported to cause allergic reactions. However, for mild allergic reaction symptoms, such as a rash, consultation with a doctor is advisable. In cases of severe reactions like swelling or trouble breathing, immediate medical assistance is required.
The drug treats brain tumors that have a specific genetic mutation in the gene for isocitrate dehydrogenase-1 (IDH1) or isocitrate dehydrogenase-2 (IDH2). These enzymes help cells produce energy, but when the genes for these enzymes are mutated, the enzymes don't work properly and contribute to tumor cell growth. By inhibiting the action of the abnormal IDH1 and IDH2 enzymes in tumor cells, Voranigo reduces tumor cell growth, slowing the progression of the brain tumor.
In addition to Voranigo, other brain tumor treatments exist, including chemotherapy with medications such as PCV combination regimen (procarbazine, lomustine, and vincristine) and temozolomide, as well as radiation therapy.
It's crucial to discuss alternative treatments with a doctor if Voranigo isn't suitable or preferable. If pregnant, using non-hormonal forms of birth control, such as condoms, while taking Voranigo and for three months after finishing is recommended due to the drug's potential impact on fertility.
