Dosage Information for Vitrakvi: Detailed Guide on Forms, Strengths, Administration, and Other Aspects
Vitrakvi, a groundbreaking oral cancer treatment, has been approved by the FDA for certain solid tumors in both adults and children. This medication comes in the form of oral capsules and solution, providing patients with an accessible treatment option.
Who Can Benefit from Vitrakvi?
Vitrakvi is prescribed for patients with solid tumors that have a confirmed neurotrophic receptor tyrosine kinase (NTRK) gene fusion, without acquired resistance mutations. These patients must also have metastatic tumors or those where surgical resection is likely to cause severe morbidity, and they should have no satisfactory alternative treatments available or have tumors that have progressed after prior therapy.
Dosage and Administration
The typical dosage of Vitrakvi (larotrectinib) for treating solid tumors in both children and adults is usually an oral once-daily regimen. While the exact milligram dose can vary based on body surface area or weight, the drug is generally dosed to achieve effective inhibition of tumors harboring NTRK gene fusions without known resistance mutations.
Oral capsules are available in 25 mg and 100 mg strengths, and the oral solution has a strength of 20 mg/mL. It is essential to note that the oral capsules should not be divided, crushed, chewed, or placed in water.
The dosage for children is based on their body surface area (BSA). In most cases, Vitrakvi oral capsules are typically taken twice per day at a dosage of 100 mg for adults, and the dosage for children is calculated according to their BSA.
Ease of Use and Special Considerations
The oral once-daily dosing of Vitrakvi increases ease of use for patients. To maintain a steady level of the drug in the body, it may be helpful to take doses around the same time of day.
Dosage adjustments may be necessary if a person takes certain medications, has liver damage, or interacts with other drugs. If trouble swallowing capsules, there are tips available for taking this form of medication. For patients using the oral solution, it is crucial to measure doses correctly, and instructions can be found on the manufacturer's website.
Long-Term Treatment
Vitrakvi is meant to be taken as a long-term treatment. However, the dosage can be affected by factors such as age, body weight and body surface area, other medications, side effects, liver function, and other medical conditions.
Accessibility and Support
Pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech for easy readability. Additionally, some pharmacies can put Vitrakvi in an easy-open container if you're having trouble opening medication bottles. If you have questions about how to use Vitrakvi oral solution, talk with your doctor or pharmacist.
It is essential to remember that while Vitrakvi and Keytruda have different forms and administration methods, they serve distinct purposes in cancer treatment.
[1] Clinical usage criteria and typical conditions for prescribing Vitrakvi are clearly described, but for precise dosing, official prescribing information or consultation with oncology pharmacy guidelines would be required.
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