Haegarda - Information on potential side effects, dosage guidance, administration methods, and additional details
Haegarda, a brand-name prescription drug, is approved by the FDA to prevent sudden, painful swelling in people with hereditary angioedema (HAE). This condition is a genetic disorder that causes episodes of severe and painful swelling, known as HAE attacks. Swelling related to HAE most commonly occurs in the airway, arms and legs, eyes, face, gastrointestinal tract, lips, and stomach.
Haegarda is suitable for adults and children aged 6 years and older. Clinical studies have shown it to be effective in reducing the frequency of HAE attacks in both children (including ages 6-12) and adults, with similar safety and efficacy profiles across these age groups.
For children aged 6-12, Haegarda is indicated and used as prophylactic therapy to prevent HAE attacks. Clinical trials have demonstrated that its administration can significantly decrease the frequency of attacks in this pediatric population, comparable to results seen in adults. In adults, Haegarda similarly prevents HAE attacks effectively, with consistent dosing protocols and a well-established safety record.
Haegarda works by raising the levels of C1-INH, a protein found naturally in human blood that plays an important role in regulating swelling, in the body. This prevents HAE attacks by keeping blood vessels and capillaries from leaking.
The dosage of Haegarda prescribed will depend on several factors, including the type and severity of the condition, weight, and any other medical conditions. Haegarda is administered as a subcutaneous injection (under the skin) twice weekly. If a dose is missed, administer it as soon as remembered, but if it's almost time for the next dose, skip the missed dose and continue with the regular dosing schedule.
It's essential to note that while Haegarda doesn't have any known interactions with alcohol, it's not recommended to consume alcohol excessively while undergoing treatment, as it may affect the management of HAE. Also, it's crucial to get Haegarda at a specialty pharmacy.
Haegarda doesn't have a generic or biosimilar form. Biologic drugs like Haegarda can't be copied exactly, so instead of generics, they have biosimilars. Financial and insurance assistance may be available through Haegarda Connect, a program offered by the manufacturer of Haegarda, CSL Behring LLC.
Mild side effects of Haegarda can include injection site reactions, dizziness, and a runny or stuffy nose. Serious side effects can include blood clots and a hypersensitivity reaction (allergic reaction). If a severe hypersensitivity reaction occurs, stop using Haegarda and call your doctor right away. If you think you've used too much Haegarda, call your doctor or the American Association of Poison Control Centers.
Haegarda hasn't been studied in people over the age of 72, but it's generally safe for older people to use. If you have any questions about the side effects of Haegarda, talk with your doctor or pharmacist.
Examples of rescue treatments for HAE attacks include C1 esterase inhibitor (Berinert), ecallantide (Kalbitor), and icatibant (Firazyr). If you have questions about your risk of blood clots while taking Haegarda, talk with your doctor.
In conclusion, Haegarda is a valuable treatment option for both children and adults with HAE, offering effective prevention of attacks with a similar safety profile across age groups. It's crucial to discuss your treatment plan with your healthcare provider to ensure the best possible outcome.
- The immunesystem plays an important role in regulating swelling, and Haegarda works by raising the levels of C1-INH, a protein found naturally in human blood, which is a part of this system.
- Haegarda is suitable for children aged 6 years and older, and it is indicated and used as prophylactic therapy to prevent HAE attacks in this pediatric population.
- Financial and insurance assistance may be available through Haegarda Connect, a program offered by the science behind the brand, CSL Behring LLC, which is a key player in the health-and-wellness industry.
- Mild side effects of Haegarda can include allergy symptoms like a runny or stuffy nose, but serious side effects can include blood clots and a hypersensitivity reaction, which is an extreme allergic response.
