Nobel Prize in Medicine 2025 Honors Pioneers of Precise Immune Therapies
The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their groundbreaking work on peripheral immune tolerance and regulatory T cells. Their discoveries are transforming cancer and autoimmune disease treatments, as well as transplantation medicine, with highly precise therapies that minimise side effects.
The laureates' research has paved the way for innovative treatments in Russia. At Sechenov University, scientists are developing a method to treat cancer using engineered regulatory T-cells. This approach allows for precise regulation of the immune system's activity in the affected area and at the optimal time. The lab is creating a TCR platform to generate therapeutic T-cells that can selectively target cancer cells. Preclinical trials of the first cellular product have shown promising results. This work is built upon the laureates' discovery of the mechanism of peripheral immune tolerance involving regulatory T-cells (Treg) and the FOXP3 gene. Collaborations with institutions like the Novosibirsk Institute of Fundamental and Clinical Immunology are further expanding the technology's capabilities.
The 2025 Nobel Prize winners' discoveries are being put into practical use in Russia, with Sechenov University leading the way in cancer treatment using regulatory T-cells. This new technology combines high-precision targeting with minimal side effects, offering hope for improved outcomes in cancer patients.
