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Perimenopause Linked to Depression in Up to 40% of Women

Hormonal shifts in perimenopause can lead to depression for many women. Understanding the link and available treatments can help navigate this challenging phase.

In this image, there is a bottle. This bottle has a label and contains some text. There is wall...
In this image, there is a bottle. This bottle has a label and contains some text. There is wall behind this bottle.

Perimenopause Linked to Depression in Up to 40% of Women

Perimenopause, the transition phase before menopause, can bring about significant changes, including depression for some women. Research indicates that up to 40% of perimenopausal women may experience depressive symptoms.

Hormonal fluctuations during perimenopause, such as rising estrogen and falling progesterone levels, can disrupt the balance of neurotransmitters like serotonin and norepinephrine, leading to mood changes and depression. These hormonal shifts are recognised as predictors of perimenopausal depression. While specific recent studies are not detailed, general research supports this link.

Symptoms of perimenopausal depression can include fatigue, cognitive slowing, lack of interest, mood swings, irritability, and sleep problems. Other risk factors include a family history of depression, obesity, prior trauma, negative attitudes towards aging and menopause, severe menopausal symptoms, and lifestyle factors like sedentary behaviour and smoking. Depression itself can even lead to early-onset perimenopause, and women using antidepressants may be three times more likely to experience this.

Managing perimenopausal depression can involve a combination of treatments. Antidepressants, particularly SSRIs and SNRIs, can help lessen hot flashes and improve mood. Home remedies like regular exercise, proper sleep, mindful breathing, valerian, and B vitamins can also be beneficial.

Perimenopausal depression, affecting up to 40% of women, is linked to hormonal changes during this phase. Understanding the symptoms, risk factors, and available treatments can help women navigate this challenging time. Further research is needed to identify specific recent studies on this relationship.

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